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Proguanil hydrochloride
CAS No. 637-32-1
Proguanil hydrochloride ( Proguanil Hydrochloride; Paludrine; Chloroguanide hydrochloride )
产品货号. M18939 CAS No. 637-32-1
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥405 | 有现货 |
|
| 10MG | ￥486 | 有现货 |
|
| 25MG | ￥826 | 有现货 |
|
| 50MG | ￥1539 | 有现货 |
|
| 100MG | ￥2754 | 有现货 |
|
| 200MG | ￥4415 | 有现货 |
|
| 500MG | ￥7112 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Proguanil hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
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产品描述Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
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同义词Proguanil Hydrochloride; Paludrine; Chloroguanide hydrochloride
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通路Autophagy
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靶点Autophagy
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受体dihydrofolate reductase;thymidylate synthase;NADH dehydrogenase
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研究领域——
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适应症——
化学信息
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CAS Number637-32-1
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分子量290.19
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分子式C11H17Cl2N5
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纯度98%
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溶解度——
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SMILESCl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
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化学全称(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gerlinde F. Plger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.
产品手册
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